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1

Allosteric Mechanisms of Molecular Machines at the Membrane: Transport by Sodium-Coupled Symporters

LeVine, Michael V., Cuendet, Michel A., Khelashvili, George, Weinstein, Harel

Journal:

Chemical Reviews

Year:

2016

Language:

english

File:

PDF, 22.42 MB

english, 2016

2

Combined in vitro and in silico approaches to the assessment of stimulant properties of novel psychoactive substances – The case of the benzofuran 5-MAPB

Sahai, Michelle A., Davidson, Colin, Khelashvili, George, Barrese, Vincenzo, Dutta, Neelakshi, Weinstein, Harel, Opacka-Juffry, Jolanta

Journal:

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Year:

2016

Language:

english

File:

PDF, 617 KB

english, 2016

3

How Structural Elements Added in Evolution From Bacterial Transporters Serve Human SLC6 Homologs

Razavi, Asghar, Khelashvili, George, Weinstein, Harel

Journal:

Biophysical Journal

Year:

2018

Language:

english

File:

PDF, 45 KB

english, 2018

4

X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

Gotfryd, Kamil, Boesen, Thomas, Mortensen, Jonas S., Khelashvili, George, Quick, Matthias, Terry, Daniel S., Missel, Julie W., LeVine, Michael V., Gourdon, Pontus, Blanchard, Scott C., Javitch, Jonath

Journal:

Nature Communications

Year:

2020

Language:

english

File:

PDF, 4.35 MB

english, 2020

5

Structural and dynamic effects of cholesterol at preferred sites of interaction with rhodopsin identified from microsecond length molecular dynamics simulations

George Khelashvili, Alan Grossfield, Scott E. Feller, Michael C. Pitman, Harel Weinstein

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2009

Language:

english

File:

PDF, 1.51 MB

english, 2009

6

Adsorption Of Bar-domain Proteins To Charged Lipid Membranes Causes Deformations And Lipid Demixing

Khelashvili, George, Harries, Daniel, Weinstein, Harel

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 37 KB

english, 2009

7

Modeling Membrane Deformations and Lipid Demixing upon Protein-Membrane Interaction: The BAR Dimer Adsorption

Khelashvili, George, Harries, Daniel, Weinstein, Harel

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 841 KB

english, 2009

8

Cholesterol Orientation and Tilt Modulus in DMPC Bilayers

Khelashvili, George, Pabst, Georg, Weinstein, Harel, Harries, Daniel

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 61 KB

english, 2010

9

Quantitative Modeling of Membrane Deformations by Multihelical Membrane Proteins: Application to G-Protein Coupled Receptors

Mondal, Sayan, Khelashvili, George, Shan, Jufang, Andersen, Olaf S., Weinstein, Harel

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 824 KB

english, 2011

10

Lateral Organization in Lipid-Cholesterol Mixed Bilayers

Pandit, Sagar A., Khelashvili, George, Jakobsson, Eric, Grama, Ananth, Scott, H.L.

Journal:

Biophysical Journal

Year:

2007

Language:

english

File:

PDF, 532 KB

english, 2007

11

Protein Diffusion on Charged Membranes: A Dynamic Mean-Field Model Describes Time Evolution and Lipid Reorganization

Khelashvili, George, Weinstein, Harel, Harries, Daniel

Journal:

Biophysical Journal

Year:

2008

Language:

english

File:

PDF, 925 KB

english, 2008

12

How Cholesterol Tilt Modulates the Mechanical Properties of Saturated and Unsaturated Lipid Membranes

Khelashvili, George, Harries, Daniel

Journal:

Journal of Physical Chemistry B

Year:

2013

Language:

english

File:

PDF, 1.87 MB

english, 2013

13

How sterol tilt regulates properties and organization of lipid membranes and membrane insertions

Khelashvili, George, Harries, Daniel

Journal:

Chemistry and Physics of Lipids

Year:

2013

Language:

english

File:

PDF, 1.99 MB

english, 2013

14

Impact of sterol tilt on membrane bending rigidity in cholesterol and 7DHC-containing DMPC membranes

Khelashvili, George, Rappolt, Michael, Chiu, See-Wing, Pabst, Georg, Harries, Daniel

Journal:

Year:

2011

Language:

english

File:

PDF, 528 KB

english, 2011

15

The Membrane Protein LeuT in Micellar Systems: Aggregation Dynamics and Detergent Binding to the S2 Site

Khelashvili, George, LeVine, Michael V., Shi, Lei, Quick, Matthias, Javitch, Jonathan A., Weinstein, Harel

Journal:

Journal of the American Chemical Society

Year:

2013

Language:

english

File:

PDF, 1.75 MB

english, 2013

16

Membrane Driven Spatial Organization of GPCRs

Mondal, Sayan, Johnston, Jennifer M., Wang, Hao, Khelashvili, George, Filizola, Marta, Weinstein, Harel

Journal:

Scientific Reports

Year:

2013

Language:

english

File:

PDF, 4.06 MB

english, 2013

17

4908203 Method for inducing HIV neutralizing antibodies using an internal image idiotope

Khelashvili, George, Grossfield, Alan, Feller, Scott E., Pitman, Michael, Weinstein, Harel

Journal:

Biotechnology Advances

Year:

1990

Language:

english

File:

PDF, 64 KB

english, 1990

18

Structural And Dynamic Effects Of Cholesterol At Preferred Sites Of Interaction With Rhodopsin Identified From Microsecond Length Molecular Dynamics Simulations

Khelashvili, George, Grossfield, Alan, Feller, Scott E., Pitman, Michael, Weinstein, Harel

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 41 KB

english, 2009

19

Molecular Dynamics simulation of a large asymmetric lipid bilayer

Scott, H. Larry, Khelashvili, George, Pandit, Sagar

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 32 KB

english, 2009

20

VALUABLE INQUIRIES IN AID OF OUR KNOWLEDGE OF PHTHISIS.

Scott, H. Larry, Khelashvili, George, Pandit, Sagar

Journal:

Year:

1842

Language:

english

File:

PDF, 115 KB

english, 1842

21

Cholesterol Modulates the Membrane Effects and Spatial Organization of Membrane-Penetrating Ligands for G-Protein Coupled Receptors

Khelashvili, George, Mondal, Sayan, Andersen, Olaf S., Weinstein, Harel

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 37 KB

english, 2011

22

Impact of Sterol Tilt on Membrane Bending Rigidity in Cholesterol and 7DHC-Containing DMPC Membrane

Khelashvili, George, Rappolt, Michael, Chiu, See-Wing, Pabst, Georg, Harries, Daniel

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 95 KB

english, 2012

23

How PIP2 Lipids Regulate the Position and Phosphorylation of the Syntaxin N-Terminus

Khelashvili, George, Galli, Aurelio, Weinstein, Harel

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 39 KB

english, 2012

24

Structural Intermediates in a Model of the Substrate Translocation Path in the Bacterial Glutamate Transporter Homologue GltPh

Stolzenberg, Sebastian, Khelashvili, George, Weinstein, Harel

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 38 KB

english, 2012

25

Large-Scale MD Simulations Reveal Structural Elements of the Activated State in the 5-HT2a Receptor and their Relation to Cholesterol Dynamics

Shan, Jufang, Khelashvili, George, Weinstein, Harel

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 72 KB

english, 2010

26

Quantitative Analysis of Membrane Deformation by Multi-Helical Transmembrane Proteins

Mondal, Sayan, Khelashvili, George, Shan, Jufang, Shi, Lei, Andersen, Olaf, Weinstein, Harel

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 37 KB

english, 2011

27

Like Fish Out of Water: Membrane Proteins in Detergent Micelles

Khelashvili, George, LeVine, Michael V., Shi, Lei, Quick, Matthias, Javitch, Jonathan A., Weinstein, Harel

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 38 KB

english, 2013

28

Pharmacologically Distinct Ligands Induce Different States of 5-HT2AR and Trigger Different Membrane Remodeling: Implications For GPCR Oligomerization

Shan, Jufang, Khelashvili, George, Mondal, Sayan, Weinstein, Harel

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 35 KB

english, 2011

29

Interaction with the Membrane Uncovers Essential Differences Between Highly Homologous GPCRs

Mondal, Sayan, Khelashvili, George, Khangulova (Johnston), Jennifer, Wang, Hao, Provasi, Davide, Andersen, Olaf S., Filizola, Marta, Weinstein, Harel

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 35 KB

english, 2012

30

Quantitative Comparison of GPCR Interactions with the Lipid Bilayer of the Cubic and Lamellar Mesophases

Khelashvili, George, Mondal, Sayan, Caffrey, Martin, Weinstein, Harel

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 59 KB

english, 2012

31

The cost of living in the membrane: A case study of hydrophobic mismatch for the multi-segment protein LeuT

Mondal, Sayan, Khelashvili, George, Shi, Lei, Weinstein, Harel

Journal:

Chemistry and Physics of Lipids

Year:

2013

Language:

english

File:

PDF, 1.78 MB

english, 2013

32

Functional Consequences of Incomplete Hydrophobic Matching at TM1 of the LeuT Transporter

Mondal, Sayan, Khelashvili, George, Shi, Lei, Weinstein, Harel

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 53 KB

english, 2013

33

Protein Partitioning in Liquid-Ordered (LO) / Liquid-Disordered (LD) Domains Depends on Lipid Composition and Protein Shape

Kollmitzer, Benjamin, Heftberger, Peter, Rappolt, Michael, Khelashvili, George, Harries, Daniel, Pabst, Georg

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 99 KB

english, 2014

34

Protein and Lipid Interactions Driving Molecular Mechanisms of in meso Crystallization

Johner, Niklaus, Mondal, Sayan, Morra, Giulia, Caffrey, Martin, Weinstein, Harel, Khelashvili, George

Journal:

Journal of the American Chemical Society

Year:

2014

Language:

english

File:

PDF, 2.99 MB

english, 2014

35

Not Just an Oil Slick: How the Energetics of Protein-Membrane Interactions Impacts the Function and Organization of Transmembrane Proteins

Mondal, Sayan, Khelashvili, George, Weinstein, Harel

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 1.94 MB

english, 2014

36

PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein

Hamilton, Peter J, Belovich, Andrea N, Khelashvili, George, Saunders, Christine, Erreger, Kevin, Javitch, Jonathan A, Sitte, Harald H, Weinstein, Harel, Matthies, Heinrich J G, Galli, Aurelio

Journal:

Nature Chemical Biology

Year:

2014

Language:

english

File:

PDF, 1.41 MB

english, 2014

37

Phosphatidylinositol 4,5-Biphosphate (PIP 2 ) Lipids Regulate the Phosphorylation of Syntaxin N-Terminus by Modulating Both Its Position and Local Structure

Khelashvili, George, Galli, Aurelio, Weinstein, Harel

Journal:

Year:

2012

Language:

english

File:

PDF, 2.95 MB

english, 2012

38

Structural Intermediates in a Model of the Substrate Translocation Path of the Bacterial Glutamate Transporter Homologue GltPh

Stolzenberg, Sebastian, Khelashvili, George, Weinstein, Harel

Journal:

Journal of Physical Chemistry B

Year:

2012

Language:

english

File:

PDF, 7.69 MB

english, 2012

39

Why GPCRs behave differently in cubic and lamellar lipidic mesophases

Khelashvili, George, Albornoz, Pedro Blecua Carrillo, Johner, Niklaus, Mondal, Sayan, Caffrey, Martin, Weinstein, Harel

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 1.92 MB

english, 2012

40

A Functional Selectivity Mechanism at the Serotonin-2A GPCR Involves Ligand-Dependent Conformations of Intracellular Loop 2

Perez-Aguilar, Jose Manuel, Shan, Jufang, LeVine, Michael V., Khelashvili, George, Weinstein, Harel

Journal:

Journal of the American Chemical Society

Year:

2014

Language:

english

File:

PDF, 3.52 MB

english, 2014

41

Cholesterol Modulates the Membrane Effects and Spatial Organization of Membrane-Penetrating Ligands for G-Protein Coupled Receptors

Khelashvili, George, Mondal, Sayan, Andersen, Olaf S., Weinstein, Harel

Journal:

Journal of Physical Chemistry B

Year:

2010

Language:

english

File:

PDF, 4.97 MB

english, 2010

42

Calculating the Bending Modulus for Multicomponent Lipid Membranes in Different Thermodynamic Phases

Khelashvili, George, Kollmitzer, Benjamin, Heftberger, Peter, Pabst, Georg, Harries, Daniel

Journal:

Journal of Chemical Theory and Computation

Year:

2013

Language:

english

File:

PDF, 1018 KB

english, 2013

43

Cholesterol Orientation and Tilt Modulus in DMPC Bilayers

Khelashvili, George, Pabst, Georg, Harries, Daniel

Journal:

Journal of Physical Chemistry B

Year:

2010

Language:

english

File:

PDF, 3.31 MB

english, 2010

44

Curvature and Lipid Packing Modulate the Elastic Properties of Lipid Assemblies: Comparing H II and Lamellar Phases

Johner, Niklaus, Harries, Daniel, Khelashvili, George

Journal:

The Journal of Physical Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.63 MB

english, 2014

45

Combined Monte Carlo and molecular dynamics simulation of hydrated 18:0 sphingomyelin–cholesterol lipid bilayers

Khelashvili, George A., Scott, H. L.

Journal:

The Journal of Chemical Physics

Year:

2004

Language:

english

File:

PDF, 343 KB

english, 2004

46

Self-consistent mean-field model based on molecular dynamics: Application to lipid-cholesterol bilayers

Khelashvili, George A., Pandit, Sagar A., Scott, H. L.

Journal:

The Journal of Chemical Physics

Year:

2005

Language:

english

File:

PDF, 1.24 MB

english, 2005

47

Transport domain unlocking sets the uptake rate of an aspartate transporter

Akyuz, Nurunisa, Georgieva, Elka R., Zhou, Zhou, Stolzenberg, Sebastian, Cuendet, Michel A., Khelashvili, George, Altman, Roger B., Terry, Daniel S., Freed, Jack H., Weinstein, Harel, Boudker, Olga, B

Journal:

Year:

2015

Language:

english

File:

PDF, 7.14 MB

english, 2015

48

GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base

Khelashvili, G., Dorff, K., Shan, J., Camacho-Artacho, M., Skrabanek, L., Vroling, B., Bouvier, M., Devi, L. A., George, S. R., Javitch, J. A., Lohse, M. J., Milligan, G., Neubig, R. R., Palczewski, K

Journal:

Year:

2010

Language:

english

File:

PDF, 73 KB

english, 2010

49

Functional mechanisms of neurotransmitter transporters regulated by lipid–protein interactions of their terminal loops

Khelashvili, George, Weinstein, Harel

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

2015

Language:

english

File:

PDF, 2.71 MB

english, 2015

50

Cholesterol under oxidative stress—How lipid membranes sense oxidation as cholesterol is being replaced by oxysterols

Kulig, Waldemar, Olżyńska, Agnieszka, Jurkiewicz, Piotr, Kantola, Anu M., Komulainen, Sanna, Manna, Moutusi, Pourmousa, Mohsen, Vazdar, Mario, Cwiklik, Lukasz, Rog, Tomasz, Khelashvili, George, Harrie

Journal:

Free Radical Biology and Medicine

Year:

2015

Language:

english

File:

PDF, 2.41 MB

english, 2015